Variation in Candida albicans EFG1 Expression Enables Host-Dependent Changes in Colonizing Fungal Populations
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چکیده
منابع مشابه
Variation in Candida albicans EFG1 Expression Enables Host-Dependent Changes in Colonizing Fungal Populations
UNLABELLED To understand differences in host-Candida albicans interactions that occur during colonization of healthy or compromised hosts, production of phenotypic variants and colonization of healthy or immunodeficient mice by C. albicans were studied. We showed that activity of the transcription factor Efg1p exhibited cell-to-cell variability and identified Efg1p as a major regulator of colon...
متن کاملInvestigation the expression Candida albicans EFG1 gene in Vaginal Candidiasis and biofilm formation
Candida albicans has the ability to change between yeast and hyphal cells and is known to be a virulence property. Efg1gene of C.albicans is as a main transcription factor that plays pivotal roles in biofilm formation The aim of the current study is to investigate the presence of Efg1 gene in Candida albicans isolates from women with vaginal candidiasis and its impact on biofilm formation.We us...
متن کاملEfg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.
The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.
متن کاملinvestigation the expression candida albicans efg1 gene in vaginal candidiasis and biofilm formation
candida albicans has the ability to change between yeast and hyphal cells and is known to be a virulence property. efg1gene of c.albicans is as a main transcription factor that plays pivotal roles in biofilm formation the aim of the current study is to investigate the presence of efg1 gene in candida albicans isolates from women with vaginal candidiasis and its impact on biofilm formation.we us...
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Filamentous growth is an important virulence trait of the human pathogenic fungi within the genus Candida, and the greater propensity of C. albicans to form hyphae has been proposed to account for the greater virulence of this species relative to the less pathogenic species C. dubliniensis. In this meta-analysis, we compare the transcriptional response of C. dubliniensis and C. albicans to the ...
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ژورنال
عنوان ژورنال: mBio
سال: 2012
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00117-12